Research Associate

📍 New York
📃 Full-Time
📅 Start Date: ASAP (Please only apply if you can start before end of November 2025, sorry!)

About Ochre Bio
Ochre Bio develops RNA therapies for chronic liver disease. Our driving vision is to end the need for liver transplants. Over 1.5 million people, globally, die of chronic liver disease every year. For the vast majority the only cure is a liver transplant. With little more than 40,000 transplants performed, this is a health lottery. Ochre exists to change this.

Our science is built on three pillars:

• Causal human discovery: The largest global collection of human liver data to uncover new therapeutic targets.
• Rigorous human validation: World-leading human models that far outclass traditional animal models.
• Better therapeutic translation: Optimised RNA chemistry and biology to bring effective therapies to patients faster.

We’re ambitious, curious, and supportive, embracing failure as part of innovation and guided by our three operating values:

• Clarke’s Law: Be bold. Think big.
• Murphy’s Law: Fail fast. Learn faster.
• Wheaton’s Law: Support each other, always.
  

The Role

We are looking for a talented and highly motivated Research Associate to join the Ochre Bio Team in NYC on an exciting journey to support the development of advanced RNA medicines for one of the most pressing healthcare challenges of our time.

Ochre’s New York site is a highly unique organ perfusion lab that deep phenotypes human livers perfused on machines, to study their responses to advanced RNA therapies. Deep phenotyping includes: tissue imaging, blood and tissue functional studies, single-cell sequencing, and precision-slice culture of liver biopsies.

This role generates the data coming out of Ochre’s liver perfusion lab. You will be expected to assist liver perfusion and process assays and imaging. You will report to the Head of Late Validation (the site head), working closely with the perfusion team to ensure robust data. The nature of the role will require regular evening and weekend work (additional compensation).

Key Responsibilities

• Sample processing and generation of phenotyping data including tissue imaging, blood and tissue functional studies and sequencing
• Executing state of the art phenotyping strategies (assays, histology, RNA and protein readouts)
• Analyze, review and interpret results
• Assisting with setting up human liver perfusions, monitoring of livers during perfusion, problem solving and responding to poor liver function, collecting samples, and preparing samples for phenotyping (full training will be provided)
• Actively collaborate and communicate with other members of Ochre Bio across all three sites (US, UK & Taiwan)

The successful candidate will embrace this challenging role and the three measures of excellence we look for in our team-members: speed, value-based innovation, and a ‘can-do’ attitude. Biotech research is a very fast paced environment which will suit you if you have an enthusiasm to grow yourself in what is currently one of the most innovative biotech companies. You have a solid scientific background and strong sense of responsibility, with excellent teamwork skills and the ability to work collaboratively with our perfusion and science teams across three continents. You are competent in following complex protocols and providing critical feedback on perfusions.

Must-haves

• BSc degree or higher in a biological science or similar field of study
• ​​Significant wet lab experience in either an academic or industry setting
• Ability to work in a fast paced environment where you have been expected to rapidly produce, analyze and present results
• Experience with molecular and cellular techniques
• Strong expertise with lab-based assays such as qPCR, western blots, cell-based assays and flow cytometry
• Experience with cell and tissue culture
• Strong organizational skills, with the ability to prioritize tasks effectively
• Methodical approach to work and record keeping
• Able to handle specimens using aseptic techniques
• Ability to work in a fast-paced environment
• High-level of attention to detail, with the ability to follow complex protocols
• Excellent interpersonal skills
  

Nice-to-haves

• Prior research experience in liver biology
• Clinical research experience
• Liver perfusion or liver lab tech experience
• Comfortable with histology (sample preparation and staining)
• Ability to analyze and present data using R
  

If you’re ready to make an impact in the fight against chronic liver disease, we’d love to hear from you 👉 Apply now!